persistent severe limb ischemia is still essentially the most widespread factors of ailment and hospitalization within the western international. curiosity in severe limb ischemia has elevated markedly lately. there were major achievements in diagnostic professional­ cedures in addition to within the clinical, invasive, and surgery of sufferers with severe limb ischemia. regardless of a substantial learn attempt, the pathophysiological mechanisms of serious limb ischemia in people is still confirmed. favorite is the expanding curiosity within the microcirculation, in addition to within the hemorheological, hemostatic and inflammatory adjustments which can advertise severe limb ischemia. extra learn is critical to quantify the relevance of microcirculatory in­ vestigations when it comes to predicting the analysis or to guage the consequences of latest treatments. Our major activity is to supply the sufferer the very best remedy in an effort to stay away from limb loss and to enhance caliber of existence. some of the equipment of remedy, their suc­ cess charges, and their issues, has to be rigorously evaluated and mentioned. This quantity offers the complicated box of prognosis and remedy of serious limb ischemia. The analysis and therapy comprises assorted experts together with angio­ logists, interventional radiologists, vascular surgeons, plastic surgeons, diabeto­ logists, and so on. person chapters were written by way of Belgian and German specialists within the quite a few specialities, who current their very own adventure. we're very thankful that those specialists have joined us to provide this publication at the epidemiology, pathophysiology, and rational therapy.